Ceramide Scores Predict Cardiovascular Risk in the Community

On validation of cardiovascular risk scores.

In predictive modeling, as reviewed by these authors, historical data are used to predict a known future. Each model produces a risk score on a scale of 0-1 (or 0-100%), but each outcome is either an event or a non-event, so the score cannot ever be “valid”, except in an extreme situation. As in many of the papers reviewed, typically the basic definition of “validation” is stretched to include ...

Scores for post-myocardial infarction risk stratification in the community.

BACKGROUND Several scores, most of which were derived from clinical trials, have been proposed for stratifying risk after myocardial infarctions (MIs). Little is known about their generalizability to the community, their respective advantages, and whether the ejection fraction (EF) adds prognostic information to the scores. The purpose of this study is to evaluate the Thrombolysis in Myocardial...

Risk scores predict atherosclerotic lesions in young people.

BACKGROUND Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons. METHODS The Pathobiological Determinants of Atherosclerosis in Youth study collected arteries and samples of blood and other tissues from persons aged 15 ...

Cardiovascular risk scores in relation to social deprivation and ethnicity.

Clinical scores to predict recurrence risk of venous thromboembolism.

Venous thromboembolism (VTE) is a common and chronic disease with a considerable risk of recurrence. Patients with unprovoked (in the absence of a transient risk factor) VTE have a recurrence risk as high as 30% within five years after cessation of anticoagulation. Depending on patient selection the case-fatality rate of recurrence ranges between 3.6%-10%. Thus, indefinite anticoagulation treat...